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Seeking Breakthrough Makers

Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.

CHOP's Commitment to Diversity, Equity, and Inclusion

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.


A Brief Overview
Will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

A postdoctoral fellow position is available in the laboratory of Dr. Liming Pei at the Center for Mitochondrial and Epigenomic Medicine, and Cardiovascular Research Institute at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania (UPenn). Our laboratory uses a range of molecular and cellular biology, mouse genetics, and single-cell multiomics technologies to study cardiovascular and metabolic biology and disease. The candidate will work closely with the other members of the research team. Our recent publications include:

Zhao, J., and Pei, L (2020). Cardiac Endocrinology: Heart-Derived Hormones in Physiology and Disease. JACC Basic Transl Sci 5, 949-960. PMID: 33015416. PMCID: PMC7524786.

Pei L, Wallace DC (2018). Mitochondrial Etiology of Neuropsychiatric Disorders. Biological Psychiatry 83, 722-730. PMID: 29290371. PMCID: PMC5891364.

Hu P, Liu J, Zhao J, Wilkins BJ, Lupino K, Wu H, Pei L. (2018). Single-nucleus transcriptomic survey of cell diversity and functional remodeling in the postnatal developing hearts. Genes & Development 32, 1344-1357. PMID: 30254108. PMCID: PMC6169839.

Zhao J, Lupino K, Wilkins BJ, Qiu C, Liu J, Omura Y, Allred AL, McDonald C, Susztak K, Barish GD, Pei L. (2018) Genomic integration of ERR-HNF1 regulates renal bioenergetics and prevents chronic kidney disease. Proceedings of National Academy of Sciences 115, E4910-E4919. PMID: 29735694. PMCID: PMC6003475.

Li J, Liu J, Lupino K, Liu X, Zhang L, Pei L. (2018) GDF15 maturation requires proteolytic cleavage by PCSK3, 5 and 6. Molecular and Cellular Biology. 38 (21). pii: e00249-18. PMID: 30104250. PMCID: PMC6189459.

Wang T, Liu J, McDonald, C, Lupino K, Zhai X, Wilkins BJ, Hakonarson H, Pei L (2017). GDF15 is a heart-derived hormone that regulates body growth. EMBO Molecular Medicine 9, 1150-1164.

Wang T, McDonald C, Petrenko NB, Leblanc M, Giguere V, Evans RM, Patel VV, Pei L (2015). ERRalpha and ERRgamma are essential coordinators of cardiac metabolism and function. Molecular and Cellular Biology 35, 1281-1298.

Pei L*, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM* (2015). Dependence of hippocampal function on ERR regulated mitochondrial metabolism. Cell Metabolism 21, 628-636 (* co-corresponding author, featured in cover).

Faculty page: http://www.med.upenn.edu/apps/faculty/index.php/g275/p8651729
Lab website: https://peilab.org
Full publication list: https://www.ncbi.nlm.nih.gov/myncbi/liming.pei.1/bibliography/public/

CHOP is an equal opportunity employer. Postdoctoral fellows are provided with comprehensive benefits package including eligible health insurance and retirement plan (http://www.research.chop.edu/careers/working-research/benefits-information) . CHOP and UPenn offer outstanding research and training environment. The lab is fully committed to the success and career development of every team member. Previous team members are currently working in both academic (universities, hospitals, etc.) and industry (pharmaceutical, biotech, etc.) positions.

Contact: Applicant should submit a cover letter detailing her/his research background and interest, why she/he is interested in joining the lab, a current CV, and names/contact information of three references to:

Liming Pei, Ph.D.

lpei@pennmedicine.upenn.edu

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

Education Qualifications

• Doctorate Required