Children's Hospital of Philadelphia
Post Doc Fellow - Oncology
Philadelphia, PA
Oct 16, 2024
Full-time
Full Job Description

SHIFT:

Day (United States of America)

A Brief Overview

Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.

The postdoctoral fellow (postdoc) and will conduct translational pediatric cancer biology, genomics, and immuno-oncology research under the direction/guidance of Dr. Kris Bosse at the Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania (UPenn). Dr. Bosse's laboratory is focused on understanding the underlying molecular mechanisms driving neuroblastoma tumorigenesis and developing new therapies, including immunotherapeutic strategies, for this and other aggressive pediatric cancers (see Bosse et al., Cancer Cell, 2017; Raman et al., Cell Reports Medicine, 2021; Heitzeneder et al., Cancer Cell, 2022; Pascual-Pasto et al, JITC, 2022, Foster et al, JITC, 2022, Pascual-Pasto et al, Nature Communications, 2024 and Pascual-Pasto et al, Clinical Cancer Research, 2024 as examples). The postdoc will join a growing translational research team based in his laboratory. Several opportunities exist to work in collaboration with several other laboratories at CHOP/UPenn and at 10 other institutions as part of the St. Baldricks-Stand Up To Cancer Immunogenomics Team in developing and validating new immunotherapeutic strategies for pediatric cancers. Multiple specific projects exist under this umbrella designed to discover and develop novel, impactful new immune-based therapies for children with cancer. Available projects include (but are not limited to) translating current immunotherapies in the lab across pediatric cancers, new immunotherapeutic target discovery in neuroblastoma and other pediatric cancers, next-generation chimeric antigen receptor (CAR) T cell therapy and antibody-drug conjugate (ADC) development, defining mechanisms of tumor cell intrinsic and extrinsic immune escape, deciphering the key biologic functions of prioritized immunotherapeutic targets, dual antigen immunotherapeutic targeting, CAR vaccination approaches, and correlative biology studies from ongoing clinical trials that developed from work done in the Bosse laboratory. The Bosse laboratory is also interested in utilizing syngeneic neuroblastoma models to define critical synergistic CAR T cell and ADC therapeutic combinations that can be translated to the clinic. Other opportunities are available in the laboratory to explore and define the underlying mechanisms of therapeutic resistance and disease progression in neuroblastoma utilizing data acquired from the serial profiling of circulating tumor DNA (ctDNA) in this disease (see Bosse et al., Cancer Discovery, 2022 as an example). Key putative genomic mechanisms of therapeutic resistance have been identified that are primed for functional validation studies. Cancer and molecular biology experience are required, and familiarity with advanced genomic and immuno-oncology techniques and methods, as well as experience with in vivo mouse models, are preferred skills. This job is open to those seeking first or second post-docs.

CHOP's Commitment to Diversity, Equity, and Inclusion
CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

Responsibilities

  • Participate in project planning, recording, and evaluation of data.

  • Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator).

  • Acquire technical, lab management, and grant writing skills.

  • Participate in seminars, lectures, poster sessions, national presentations, and professional workshops.

  • Supervise junior lab members.

  • Assist with other research projects as needed.

Education

  • Required: Doctorate

PDN-9d419903-eef5-4a0e-a124-3f93b95d83fd
Job Information
Job Category:
Other
Spotlight Employer
Related jobs
Milaca Elim Meadows, a 5-star rated,70-bed senior care campus with a 12-bed Rehab Unit, is hiring Full-Time andPart-TimeCertified Nursing Assistants (CNAs)to join our skilled team. In this role, you w...
Nov 25, 2024
Milaca, MN
Description:Filter Services Inc., (FSI) is a leading Master Distributor of filtration-related products, catering to diverse industries. Known for exceptional Commercial and Industrial Air Filter Chang...
Nov 25, 2024
Chicago, IL
Maintenance Technician
Park7 Management LLC
We are looking for the best of the best! COMPANY OVERVIEW: Park7 Management is a fast-growing leader in the student housing industry, with a corporate office in New York and properties nationwide. Our...
Nov 25, 2024
San Marcos, TX
©2024 Kappa Alpha Psi Fraternity, Inc.
Powered by TalentAlly.
Apply for this job
Post Doc Fellow - Oncology
Children's Hospital of Philadelphia
Philadelphia, PA
Oct 16, 2024
Full-time
Your Information
First Name *
Last Name *
Email Address *
Zip Code *
Password *
Confirm Password *
Create your Profile from your Resume
By clicking the Apply button, you agree to the terms of use and privacy policy.
Continue to Apply

Children's Hospital of Philadelphia would like you to finish the application on their website.

Ace your interview with AI-powered interview practice

Get comfortable talking to hiring managers, receive personalized feedback on areas for improvement, sharpen your ability to answer the most common questions, and build confidence in formulating strong responses on the spot. Click the button below to begin your three free virtual interviews!